Tamoxifen Citrate/ Nolvadex
1. Synonyms: Tamoxifen Citrate, Nolvadex, Zitazonium, Tamoxifen
2. Molecular Formula: C26H29NO.C6H8O7
3. Molecular weight: 563.64
4. CAS NO.: 54965-24-1
5. Appearance: white crystalline powder
6. MP: 140-144 oC
Tamoxifen is an antagonist of the estrogen receptor in breast tissue via its active metabolite, 4-hydroxytamoxifen. In other tissues such as the endometrium, it behaves as an agonist, and thus may be characterized as a selective estrogen-receptor modulator. Tamoxifen is the usual endocrine (anti-estrogen) therapy for hormone receptor-positive breast cancer in pre-menopausal women, and is also a standard in post-menopausal women although aromatase inhibitors are also frequently used in that setting.
1. Tamoxifen is used for treatment of breast cancer.
2. Tamoxifen is used for treatment of McCune-Albright syndrome
3. Tamoxifen is used for treatment of infertility
4. Tamoxifen is used for treatment of gynecomastia
5. Tamoxifen is used for treatment of bipolar disorder
6. Tamoxifen is used for treatment of Angiogenesis and cancer
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